GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs41997 | 1 | rs56224502 | chr7:118015311 | ANKRD7 | chr7:117864712-117882782:+ | 0.27 | 4.41 | 1.26E-5 | Response to platinum-based chemotherapy in non-small-cell lung cancer |
| THCA | cis | rs11125529 | 1 | rs56227395 | chr2:54487496 | C2orf73 | chr2:54558071-54588714:+ | 0.33 | 4.93 | 1.15E-6 | Telomere length |
| THCA | cis | rs7116495 | 1 | rs562469 | chr11:71569843 | FAM86C | chr11:71498557-71512276:+ | -0.38 | -4.6 | 5.47E-6 | Severe influenza A (H1N1) infection |
| THCA | cis | rs2292096 | 1 | rs56255908 | chr1:200724009 | DDX59 | chr1:200610119-200639126:- | -0.28 | -4.16 | 3.79E-5 | Epilepsy |
| THCA | cis | rs754466 | 1 | rs56256440 | chr10:79698207 | DLG5 | chr10:79550551-79686348:- | 0.22 | 3.56 | 0.000404 | Liver enzyme levels (gamma-glutamyl transferase) |
| THCA | cis | rs9650315 | 1 | rs56261906 | chr8:57158479 | LYN | chr8:56792386-56923936:+ | -0.15 | -3.86 | 0.000127 | Height |
| THCA | cis | rs1552244 | 1 | rs56270432 | chr3:10087517 | C3orf10 | chr3:10157333-10168873:+ | -0.19 | -4.12 | 4.51E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs56270432 | chr3:10087517 | VHL | chr3:10183319-10193744:+ | -0.17 | -4.04 | 6.27E-5 | Alzheimer's disease |
| THCA | cis | rs1335645 | 1 | rs56273250 | chr1:111675762 | DRAM2 | chr1:111659955-111682838:- | -0.29 | -4.47 | 9.79E-6 | Liver enzyme levels (gamma-glutamyl transferase) |
| THCA | cis | rs9902453 | 1 | rs56280226 | chr17:28429575 | ANKRD13B | chr17:27916801-27941778:+ | 0.36 | 8.87 | 1.41E-17 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs56280226 | chr17:28429575 | CORO6 | chr17:27941774-27948441:- | 0.51 | 12.06 | 1.98E-29 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs56280226 | chr17:28429575 | EFCAB5 | chr17:28256874-28435469:+ | 0.59 | 11.31 | 2.0E-26 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs56280226 | chr17:28429575 | GIT1 | chr17:27900487-27916610:- | 0.28 | 6.66 | 7.53E-11 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs56280226 | chr17:28429575 | LRRC37B2 | chr17:28903483-28992715:+ | 0.17 | 3.65 | 0.000288 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs56280226 | chr17:28429575 | SSH2 | chr17:27952965-28257018:- | 0.35 | 8.14 | 3.41E-15 | Coffee consumption (cups per day) |